Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak.
Identifieur interne : 001060 ( Main/Exploration ); précédent : 001059; suivant : 001061Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak.
Auteurs : Hubert Blain [France] ; Yves Rolland [France] ; Edouard Tuaillon [France] ; Nadia Giacosa [France] ; Mylène Albrand [France] ; Audrey Jaussent [France] ; Athanase Benetos [France] ; Stéphanie Miot [France] ; Jean Bousquet (allergologue) [France]Source :
- Journal of the American Medical Directors Association [ 1538-9375 ] ; 2020.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Anticorps antiviraux (analyse), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (épidémiologie), Maisons de repos (organisation et administration), Mâle (MeSH), Pandémies (MeSH), Personnel de santé (statistiques et données numériques), Pneumopathie virale (diagnostic), Pneumopathie virale (épidémiologie), Réaction de polymérisation en chaine en temps réel (méthodes), Santé au travail (statistiques et données numériques), Sécurité des patients (statistiques et données numériques), Techniques de laboratoire clinique (méthodes), Techniques de laboratoire clinique (statistiques et données numériques), Transmission verticale de maladie infectieuse (prévention et contrôle), Traçage des contacts (méthodes), Traçage des contacts (statistiques et données numériques), Épidémies de maladies (prévention et contrôle), Établissements de soins qualifiés (organisation et administration), États-Unis (épidémiologie).
- MESH :
- analyse : ADN viral, Anticorps antiviraux.
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- méthodes : Réaction de polymérisation en chaine en temps réel, Techniques de laboratoire clinique, Traçage des contacts.
- organisation et administration : Maisons de repos, Établissements de soins qualifiés.
- prévention et contrôle : Transmission verticale de maladie infectieuse, Épidémies de maladies.
- statistiques et données numériques : Personnel de santé, Santé au travail, Sécurité des patients, Techniques de laboratoire clinique, Traçage des contacts.
- épidémiologie : Infections à coronavirus, Pneumopathie virale, États-Unis.
- Femelle, Humains, Mâle, Pandémies.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Antibodies, Viral (analysis), Clinical Laboratory Techniques (methods), Clinical Laboratory Techniques (statistics & numerical data), Contact Tracing (methods), Contact Tracing (statistics & numerical data), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), DNA, Viral (analysis), Disease Outbreaks (prevention & control), Female (MeSH), Health Personnel (statistics & numerical data), Humans (MeSH), Infectious Disease Transmission, Vertical (prevention & control), Male (MeSH), Nursing Homes (organization & administration), Occupational Health (statistics & numerical data), Outcome Assessment, Health Care (MeSH), Pandemics (MeSH), Patient Safety (statistics & numerical data), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Real-Time Polymerase Chain Reaction (methods), Skilled Nursing Facilities (organization & administration), United States (epidemiology).
- MESH :
- chemical , analysis : Antibodies, Viral, DNA, Viral.
- geographic , epidemiology : United States.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- methods : Clinical Laboratory Techniques, Contact Tracing, Real-Time Polymerase Chain Reaction.
- organization & administration : Nursing Homes, Skilled Nursing Facilities.
- prevention & control : Disease Outbreaks, Infectious Disease Transmission, Vertical.
- statistics & numerical data : Clinical Laboratory Techniques, Contact Tracing, Health Personnel, Occupational Health, Patient Safety.
- Female, Humans, Male, Outcome Assessment, Health Care, Pandemics.
Abstract
OBJECTIVE
To assess the American Testing Guidance for Nursing Homes (NHs)-updated May 19, 2020-with a new COVID-19 case.
DESIGN
Case investigation.
SETTING AND SUBJECTS
All 79 residents and 34 health care personnel (HCP) of an NH.
METHODS
Seven days after identification of a COVID-19 resident, all residents and HCP underwent real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) testing for SARS-CoV-2 with nasopharyngeal swabs. This was repeated weekly in all previously negative subjects until the testing identified no new cases, and in all positive subjects until the testing was negative. COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. Standard IPC was also implemented in all HCP. Six weeks after initial testing, all residents underwent testing for enzyme-linked immunosorbent assay-based IgG antibodies directed against the SARS-CoV-2. Symptoms were serially recorded in residents and HCP.
RESULTS
A total of 36 residents had a positive rRT-PCR at baseline and 2 at day 7. Six HCP had a positive rRT-PCR at baseline and 2 at day 7. No new COVID-19 cases were diagnosed later. Among the SARS-CoV-2-positive cases, 6 residents (16%) and 3 HCP (37%) were asymptomatic during the 14 days before testing. Twenty-five residents (92.3%) and all 8 HCP (100%) with a positive rRT-PCR developed IgG antibodies against SARS-CoV-2. Among the residents and HCP always having tested negative, 2 (5%) and 5 (11.5%), respectively, developed IgG antibodies against SARS-CoV-2. These 2 residents had typical COVID-19 symptoms before and after testing and 2/5 HCP were asymptomatic before and after testing.
CONCLUSIONS AND IMPLICATIONS
This study shows the validity of the updated American Testing Guidance for Nursing Homes (NHs). It suggests implementing COVID-19 IPC in both residents and HCP with positive testing or COVID-19 symptoms and warns that asymptomatic HCP with repeated negative rRT-PCR testing can develop antibodies against SARS-CoV-2.
DOI: 10.1016/j.jamda.2020.06.013
PubMed: 32674822
PubMed Central: PMC7287418
Affiliations:
- France
- Grand Est, Languedoc-Roussillon, Lorraine (région), Midi-Pyrénées, Occitanie (région administrative)
- Montpellier, Nancy, Toulouse
- Centre hospitalier universitaire de Montpellier, Université de Lorraine, Université de Montpellier
Links toward previous steps (curation, corpus...)
Le document en format XML
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Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany; MACVIA-France, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Charité, Universitätsmedizin Berlin, Humboldt-Universität Berlin, Berlin, Germany; Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany; MACVIA-France, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><placeName><settlement type="city">Montpellier</settlement><region type="old region" nuts="2">Languedoc-Roussillon</region><region type="region" nuts="2">Occitanie (région administrative)</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire de Montpellier</orgName><orgName type="institution">Université de Montpellier</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32674822</idno><idno type="pmid">32674822</idno><idno type="doi">10.1016/j.jamda.2020.06.013</idno><idno type="pmc">PMC7287418</idno><idno type="wicri:Area/Main/Corpus">000942</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000942</idno><idno type="wicri:Area/Main/Curation">000942</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000942</idno><idno type="wicri:Area/Main/Exploration">000942</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak.</title><author><name sortKey="Blain, Hubert" sort="Blain, Hubert" uniqKey="Blain H" first="Hubert" last="Blain">Hubert Blain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France. Electronic address: h-blain@chu-montpellier.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Geriatrics, Montpellier University Hospital, Montpellier University</wicri:regionArea><wicri:noRegion>Montpellier University</wicri:noRegion><wicri:noRegion>Montpellier University</wicri:noRegion></affiliation></author><author><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, INSERM 1027, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, INSERM 1027, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Tuaillon, Edouard" sort="Tuaillon, Edouard" uniqKey="Tuaillon E" first="Edouard" last="Tuaillon">Edouard Tuaillon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Montpellier University Hospital, INSERM 1058, Montpellier University, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, Montpellier University Hospital, INSERM 1058, Montpellier University</wicri:regionArea><wicri:noRegion>Montpellier University</wicri:noRegion><wicri:noRegion>Montpellier University</wicri:noRegion></affiliation></author><author><name sortKey="Giacosa, Nadia" sort="Giacosa, Nadia" uniqKey="Giacosa N" first="Nadia" last="Giacosa">Nadia Giacosa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Geriatrics, Montpellier University Hospital, Montpellier University</wicri:regionArea><wicri:noRegion>Montpellier University</wicri:noRegion><wicri:noRegion>Montpellier University</wicri:noRegion></affiliation></author><author><name sortKey="Albrand, Mylene" sort="Albrand, Mylene" uniqKey="Albrand M" first="Mylène" last="Albrand">Mylène Albrand</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Geriatrics, Montpellier University Hospital, Montpellier University</wicri:regionArea><wicri:noRegion>Montpellier University</wicri:noRegion><wicri:noRegion>Montpellier University</wicri:noRegion></affiliation></author><author><name sortKey="Jaussent, Audrey" sort="Jaussent, Audrey" uniqKey="Jaussent A" first="Audrey" last="Jaussent">Audrey Jaussent</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Information, University Hospital of Montpellier, University of Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Information, University Hospital of Montpellier, University of Montpellier</wicri:regionArea><wicri:noRegion>University of Montpellier</wicri:noRegion><wicri:noRegion>University of Montpellier</wicri:noRegion></affiliation></author><author><name sortKey="Benetos, Athanase" sort="Benetos, Athanase" uniqKey="Benetos A" first="Athanase" last="Benetos">Athanase Benetos</name><affiliation wicri:level="4"><nlm:affiliation>Department of Geriatrics, CHRU de Nancy and Inserm DCAC, Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Geriatrics, CHRU de Nancy and Inserm DCAC, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Miot, Stephanie" sort="Miot, Stephanie" uniqKey="Miot S" first="Stéphanie" last="Miot">Stéphanie Miot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Geriatrics, Montpellier University Hospital, Montpellier University</wicri:regionArea><wicri:noRegion>Montpellier University</wicri:noRegion><wicri:noRegion>Montpellier University</wicri:noRegion></affiliation></author><author><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet (allergologue)</name><affiliation wicri:level="3"><nlm:affiliation>Charité, Universitätsmedizin Berlin, Humboldt-Universität Berlin, Berlin, Germany; Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany; MACVIA-France, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Charité, Universitätsmedizin Berlin, Humboldt-Universität Berlin, Berlin, Germany; Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany; MACVIA-France, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><placeName><settlement type="city">Montpellier</settlement><region type="old region" nuts="2">Languedoc-Roussillon</region><region type="region" nuts="2">Occitanie (région administrative)</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire de Montpellier</orgName><orgName type="institution">Université de Montpellier</orgName></affiliation></author></analytic><series><title level="j">Journal of the American Medical Directors Association</title><idno type="eISSN">1538-9375</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (analysis)</term><term>Clinical Laboratory Techniques (methods)</term><term>Clinical Laboratory Techniques (statistics & numerical data)</term><term>Contact Tracing (methods)</term><term>Contact Tracing (statistics & numerical data)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>DNA, Viral (analysis)</term><term>Disease Outbreaks (prevention & control)</term><term>Female (MeSH)</term><term>Health Personnel (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Infectious Disease Transmission, Vertical (prevention & control)</term><term>Male (MeSH)</term><term>Nursing Homes (organization & administration)</term><term>Occupational Health (statistics & numerical data)</term><term>Outcome Assessment, Health Care (MeSH)</term><term>Pandemics (MeSH)</term><term>Patient Safety (statistics & numerical data)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Real-Time Polymerase Chain Reaction (methods)</term><term>Skilled Nursing Facilities (organization & administration)</term><term>United States (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term><term>Anticorps antiviraux (analyse)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (épidémiologie)</term><term>Maisons de repos (organisation et administration)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Personnel de santé (statistiques et données numériques)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (épidémiologie)</term><term>Réaction de polymérisation en chaine en temps réel (méthodes)</term><term>Santé au travail (statistiques et données numériques)</term><term>Sécurité des patients (statistiques et données numériques)</term><term>Techniques de laboratoire clinique (méthodes)</term><term>Techniques de laboratoire clinique (statistiques et données numériques)</term><term>Transmission verticale de maladie infectieuse (prévention et contrôle)</term><term>Traçage des contacts (méthodes)</term><term>Traçage des contacts (statistiques et données numériques)</term><term>Épidémies de maladies (prévention et contrôle)</term><term>Établissements de soins qualifiés (organisation et administration)</term><term>États-Unis (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term><term>DNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Laboratory Techniques</term><term>Contact Tracing</term><term>Real-Time Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Réaction de polymérisation en chaine en temps réel</term><term>Techniques de laboratoire clinique</term><term>Traçage des contacts</term></keywords><keywords scheme="MESH" qualifier="organisation et administration" xml:lang="fr"><term>Maisons de repos</term><term>Établissements de soins qualifiés</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Nursing Homes</term><term>Skilled Nursing Facilities</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Outbreaks</term><term>Infectious Disease Transmission, Vertical</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Transmission verticale de maladie infectieuse</term><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Clinical Laboratory Techniques</term><term>Contact Tracing</term><term>Health Personnel</term><term>Occupational Health</term><term>Patient Safety</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Personnel de santé</term><term>Santé au travail</term><term>Sécurité des patients</term><term>Techniques de laboratoire clinique</term><term>Traçage des contacts</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>États-Unis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Outcome Assessment, Health Care</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To assess the American Testing Guidance for Nursing Homes (NHs)-updated May 19, 2020-with a new COVID-19 case.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Case investigation.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING AND SUBJECTS</b></p><p>All 79 residents and 34 health care personnel (HCP) of an NH.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Seven days after identification of a COVID-19 resident, all residents and HCP underwent real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) testing for SARS-CoV-2 with nasopharyngeal swabs. This was repeated weekly in all previously negative subjects until the testing identified no new cases, and in all positive subjects until the testing was negative. COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. Standard IPC was also implemented in all HCP. Six weeks after initial testing, all residents underwent testing for enzyme-linked immunosorbent assay-based IgG antibodies directed against the SARS-CoV-2. Symptoms were serially recorded in residents and HCP.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 36 residents had a positive rRT-PCR at baseline and 2 at day 7. Six HCP had a positive rRT-PCR at baseline and 2 at day 7. No new COVID-19 cases were diagnosed later. Among the SARS-CoV-2-positive cases, 6 residents (16%) and 3 HCP (37%) were asymptomatic during the 14 days before testing. Twenty-five residents (92.3%) and all 8 HCP (100%) with a positive rRT-PCR developed IgG antibodies against SARS-CoV-2. Among the residents and HCP always having tested negative, 2 (5%) and 5 (11.5%), respectively, developed IgG antibodies against SARS-CoV-2. These 2 residents had typical COVID-19 symptoms before and after testing and 2/5 HCP were asymptomatic before and after testing.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS AND IMPLICATIONS</b></p><p>This study shows the validity of the updated American Testing Guidance for Nursing Homes (NHs). It suggests implementing COVID-19 IPC in both residents and HCP with positive testing or COVID-19 symptoms and warns that asymptomatic HCP with repeated negative rRT-PCR testing can develop antibodies against SARS-CoV-2.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32674822</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-9375</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of the American Medical Directors Association</Title><ISOAbbreviation>J Am Med Dir Assoc</ISOAbbreviation></Journal><ArticleTitle>Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak.</ArticleTitle><Pagination><MedlinePgn>933-936</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1525-8610(20)30518-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jamda.2020.06.013</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the American Testing Guidance for Nursing Homes (NHs)-updated May 19, 2020-with a new COVID-19 case.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Case investigation.</AbstractText><AbstractText Label="SETTING AND SUBJECTS" NlmCategory="METHODS">All 79 residents and 34 health care personnel (HCP) of an NH.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Seven days after identification of a COVID-19 resident, all residents and HCP underwent real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) testing for SARS-CoV-2 with nasopharyngeal swabs. This was repeated weekly in all previously negative subjects until the testing identified no new cases, and in all positive subjects until the testing was negative. COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. Standard IPC was also implemented in all HCP. Six weeks after initial testing, all residents underwent testing for enzyme-linked immunosorbent assay-based IgG antibodies directed against the SARS-CoV-2. Symptoms were serially recorded in residents and HCP.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 36 residents had a positive rRT-PCR at baseline and 2 at day 7. Six HCP had a positive rRT-PCR at baseline and 2 at day 7. No new COVID-19 cases were diagnosed later. Among the SARS-CoV-2-positive cases, 6 residents (16%) and 3 HCP (37%) were asymptomatic during the 14 days before testing. Twenty-five residents (92.3%) and all 8 HCP (100%) with a positive rRT-PCR developed IgG antibodies against SARS-CoV-2. Among the residents and HCP always having tested negative, 2 (5%) and 5 (11.5%), respectively, developed IgG antibodies against SARS-CoV-2. These 2 residents had typical COVID-19 symptoms before and after testing and 2/5 HCP were asymptomatic before and after testing.</AbstractText><AbstractText Label="CONCLUSIONS AND IMPLICATIONS" NlmCategory="CONCLUSIONS">This study shows the validity of the updated American Testing Guidance for Nursing Homes (NHs). It suggests implementing COVID-19 IPC in both residents and HCP with positive testing or COVID-19 symptoms and warns that asymptomatic HCP with repeated negative rRT-PCR testing can develop antibodies against SARS-CoV-2.</AbstractText><CopyrightInformation>Copyright © 2020 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Blain</LastName><ForeName>Hubert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France. Electronic address: h-blain@chu-montpellier.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolland</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, INSERM 1027, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuaillon</LastName><ForeName>Edouard</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Virology, Montpellier University Hospital, INSERM 1058, Montpellier University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giacosa</LastName><ForeName>Nadia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albrand</LastName><ForeName>Mylène</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaussent</LastName><ForeName>Audrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical Information, University Hospital of Montpellier, University of Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benetos</LastName><ForeName>Athanase</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, CHRU de Nancy and Inserm DCAC, Université de Lorraine, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miot</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Montpellier University Hospital, Montpellier University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bousquet</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Charité, Universitätsmedizin Berlin, Humboldt-Universität Berlin, Berlin, Germany; Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany; MACVIA-France, Montpellier, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Am Med Dir Assoc</MedlineTA><NlmUniqueID>100893243</NlmUniqueID><ISSNLinking>1525-8610</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016358" MajorTopicYN="N">Contact Tracing</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006282" MajorTopicYN="N">Health Personnel</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018445" MajorTopicYN="N">Infectious Disease Transmission, Vertical</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009735" MajorTopicYN="N">Nursing Homes</DescriptorName><QualifierName UI="Q000458" MajorTopicYN="Y">organization & administration</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016272" MajorTopicYN="N">Occupational Health</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment, Health Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061214" MajorTopicYN="N">Patient Safety</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012866" MajorTopicYN="N">Skilled Nursing Facilities</DescriptorName><QualifierName UI="Q000458" MajorTopicYN="N">organization & administration</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">antibodies against SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">nursing home</Keyword><Keyword MajorTopicYN="N">rRT-PCR</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32674822</ArticleId><ArticleId IdType="pii">S1525-8610(20)30518-1</ArticleId><ArticleId IdType="doi">10.1016/j.jamda.2020.06.013</ArticleId><ArticleId IdType="pmc">PMC7287418</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2020 May 21;382(21):2005-2011</Citation><ArticleIdList><ArticleId IdType="pubmed">32220208</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 May 28;382(22):2081-2090</Citation><ArticleIdList><ArticleId IdType="pubmed">32329971</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 6;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32374370</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 Jun 3;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32504735</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Languedoc-Roussillon</li><li>Lorraine (région)</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li><li>Nancy</li><li>Toulouse</li></settlement><orgName><li>Centre hospitalier universitaire de Montpellier</li><li>Université de Lorraine</li><li>Université de Montpellier</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Blain, Hubert" sort="Blain, Hubert" uniqKey="Blain H" first="Hubert" last="Blain">Hubert Blain</name></noRegion><name sortKey="Albrand, Mylene" sort="Albrand, Mylene" uniqKey="Albrand M" first="Mylène" last="Albrand">Mylène Albrand</name><name sortKey="Benetos, Athanase" sort="Benetos, Athanase" uniqKey="Benetos A" first="Athanase" last="Benetos">Athanase Benetos</name><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet (allergologue)</name><name sortKey="Giacosa, Nadia" sort="Giacosa, Nadia" uniqKey="Giacosa N" first="Nadia" last="Giacosa">Nadia Giacosa</name><name sortKey="Jaussent, Audrey" sort="Jaussent, Audrey" uniqKey="Jaussent A" first="Audrey" last="Jaussent">Audrey Jaussent</name><name sortKey="Miot, Stephanie" sort="Miot, Stephanie" uniqKey="Miot S" first="Stéphanie" last="Miot">Stéphanie Miot</name><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name><name sortKey="Tuaillon, Edouard" sort="Tuaillon, Edouard" uniqKey="Tuaillon E" first="Edouard" last="Tuaillon">Edouard Tuaillon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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